Modafinil or benzhydrylsulfinylacetamide – central stimulant (psychostimulant). FDA approved substance for the treatment of narcolepsy (a disease characterized by sudden and uncontrollable episodes of deep sleep, fatigue or excessive sleepiness), sleep apnea, and sleep disorders caused by changes in the operating mode. Quality tests have been conducted of the drug, including, as a means for the treatment of Alzheimer’s disease, depression and attention deficit disorder. Modafinil belongs to the group of drugs known as evgeroiki (stimulators) that promote mental alertness and attention. One of the known mechanisms of action of these drugs is agonism alpha 1-adrenoceptor, resulting in drugs affect mood, increasing energy by increasing dopamine release in the central nervous system. It also leads to changes in the levels of GABA and glutamate. In studies of modafinil as a stimulant were shown benefits of the drug compared with amphetamines. Let’s start with the fact that the substance is expected to have a much lower potential for abuse due to the fact that its impact does not cause the same euphoria. Moreover, the drug has minimal effect on peripheral CNS stimulation (i.e., exhibit less side effects), has a minimal effect on blood pressure, does not cause sleep interruptions (without hangover or needs “catch” sleep), and, according to clinical trials, It has a more robust safety profile. The drug is used, even the US armed forces as an energy stimulant for pilots and soldiers required to operate for long periods of time without sleep. This is not as strange as it may seem at first glance, as in the past, military pilots and soldiers is widely used Dexedrine (amphetamine) during long periods of sleep deprivation. Soldiers who use modafinil, often report that the drug helps them to maintain excellent cognitive function for up to 40 hours without sleep, and has fewer side effects than Dexedrine. Modafinil has been tested in recent combat situations, such as Afghanistan and Iraq, and possibly in the future will receive official recognition as a special preparation for the military. Recently, modafinil has gained popularity among competitive athletes. They use it not only as a preparation for the “courage”, and as a stimulant that increases performance and endurance. Such use is likely to be a surprise for this drug developers, as it was reported earlier that the “soft” drug increases alertness does not have strong stimulatory effects, and can not improve athletic performance. Recent studies contradict these statements. A study in Canada found that taking modafinil can provide a pronounced sporting advantage. In a double blind study 15 male volunteers took the drug at a dose of 4 mg per kg body weight (equivalent to 200 mg for a person weighing 220 pounds) or placebo. Three hours after the meal carried aerobic exercises on a bicycle ergometer at 85% of maximum aerobic capacity, until exhaustion. Taking modafinil men could exercise over much longer periods of time (up to 30% longer), and used more oxygen intake during exercise. Also reported a decrease in the perceived tension, resulting in marked increase in performance during exercise.
Side effects and overdose
Most often, patients complain of:
- Dry mouth;
- Nausea or diarrhea;
- Nasal congestion;
- Back pain;
An obvious consequence of receiving modafinil may be insomnia. Such reactions often disappear within a few days from the start of treatment, or at lower dosage.
In addition, there may be:
- Allergic reactions of varying severity;
- Impaired liver function;
- Ulceration of the mucosa of the mouth;
- Increased body temperature;
When you see these symptoms, discontinue the use of modafinil and consult a doctor, who appointed him. In some cases, hospitalization is required.
In overdose arise strong jitters, heartbeat, blood pressure rise. Man needs inspection specialists and medical assistance.