Humog (INN menotropin) is a preparation of human menopausal gonadotropin. It consists of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are necessary for the normal maturation of gametes (folliculogenesis in women and spermatogenesis in men) and for the production of sex steroid hormones. Menotropin acts in women – on the ovaries and stimulates the maturation of follicles, raises the level of estrogens, stimulates the proliferation of the endometrium, in men – stimulates spermatogenesis by affecting the cells of Sertoli seed tubules, stimulates the formation and activation of testosterone and spermatogenesis. In addition, the drug can be successfully used to stimulate the development of more than one follicle in assisted reproduction programs (in vitro fertilization and embryo transfer (IVF and PE) and transfer of gametes into the fallopian tube (GIFT). Menotropin is usually used in combination with human chorionic gonadotropin. The administration of drugs can be either sequential (with induction of ovulation or controlled hyperstimulation), or alternating (with Leydig cell stimulation).
Indications for use of the drug HuMoG:
In women: infertility – ovarian hypofunction, amenorrhea (primary or secondary central genesis, hypomenstrual syndrome); Shihaen’s syndrome, Chiari-Frommel syndrome; Slowing down the growth of one dominant follicle, stimulation of superovulation (growth of a multitude of follicles for assistive reproductive techniques that facilitate the onset of conception);
In men: infertility – oppression of spermatogenesis (azoospermia, oligospermia due to primary or secondary hypogonadotropic hypogonadism), stimulation of spermatogenesis in combination with HG.
Hypersensitivity, tumors of the hypothalamic-pituitary region, hyperprolactinaemia, adrenal and thyroid gland diseases; For women – persistent enlargement of the ovaries, ovarian cyst (not due to the presence of polycystic ovary syndrome), polycystic ovary syndrome, genital tract anomalies (incompatible with normal pregnancy course), uterine myoma, metrorrhagia (unexplained etiology), estrogen-dependent tumors (ovarian cancer, cancer Uterus, breast cancer), primary failure of the ovaries, pregnancy, lactation period; For men – prostate cancer, testicular tumor, androgen-dependent tumors.